Academic Title Research Technologist Categories Academic Organization Pennsylvania State University Location University Park, PA Website https://psu.jobs/job/90008 Contact firstname.lastname@example.org Job Information The Kellogg Laboratory in the Department of Veterinary and Biomedical Sciences at Penn State has an exciting opportunity for an individual interested in a Research Technologist position. Our research focuses on developing and applying metabolomics approaches to improve our understanding of bioactive natural products and chemical ecology. The candidate will perform a range of duties, including bacterial and/or fungal culture and assays, chemical and biological sample preparation, chemical separation, data acquisition, instrumental analysis (LC-MS and NMR) and data interpretation. They will be responsible for maintaining culture stocks, and managing general laboratory operations such as ordering supplies, tracking expenses, keeping the lab up-to-date and compliant with institutional guidelines, and helping train personnel/students in laboratory techniques. The ideal candidate will have good organizational skills and motivation to learn new techniques, communicate effectively, both orally and in writing, and a successful candidate will be expected to function independently. Most importantly, the candidate will have a willingness and ability to contribute to a team-oriented research environment, having a positive attitude that promotes and facilitates the success of everyone in the lab. Qualifications: This job will be filled as a level 1, or level 2, depending upon the successful candidate’s competencies, education, and experience. Level 1 typically requires a BS or higher plus one year of related experience. Additional experience and/or education and competencies are required for level 2 placement. Experience in chemistry, biology, biochemistry, or related field is needed, and skills in cell culture, chemical extraction and chemistry instrumentation, or bioinformatics/statistics are advantageous. Review of applications will begin August 2019 and will continue until a successful candidate is identified. The desired start date is Fall 2019. Title PhD position (E13 TV-L, 50%) in Natural Products Discovery Categories Academic Organization University of Tuebingen Location Tuebingen, Germany Website https://uni-tuebingen.de/fakultaeten/mathematisch-naturwissenschaftliche-fakultaet/fachbereiche/interfakultaere-institute-und-zentren/imit/ Contact email@example.com Job Information The research group “NatResource” at the Eberhard Karls University Tuebingen is looking for a PhD student to isolate and characterize new antibacterial natural products from microbes. We are a young and highly motivated research team at the interface of natural products isolation and synthetic organic chemistry with special interest in finding new antibiotics. As part of Cluster of Excellence: CMFI – Controlling Microbes to Fight Infections, we seek an enthusiastic scientist with a Masters in Natural Products Chemistry, Synthetic Organic Chemistry, Microbiology, Biochemistry, or closely related disciplines. The project is focused on finding new lead compounds for the treatment of bacterial infections. Candidates are expected to be highly interested in natural products and organic chemistry. The position is initially funded for 3 years. Interested scientists should submit their application documents (CV, motivation letter, 2 references, grade transcripts) as a single .pdf-file via email to: firstname.lastname@example.org by Sept 1st 2018. The website of the PI can currently be found at: http://hughes.ucsd.edu. Equal opportunities are an integral part of our personnel policy, we therefore particularly encourage qualified women to apply. Disabled persons with otherwise equal qualifications are given priority. Title PhD Student in Pharmacognosy Categories Academic Organization University of Bordeaux Location France Website https://www.bjonnh.net/share/bordeaux_phd_offer.pdf Contact email@example.com Job Information Supervision Supervisor: Prof. Pierre Waffo-Téguo (firstname.lastname@example.org) Co-supervisor: Dr. Caroline Rouger (email@example.com) Project description Crops contamination with mycotoxins leads to ca. 25% global losses each year. In Europe, cereals and grapevine are the crops most concerned by this issue, being affected by mycotoxins produced by Fusarium graminearum (deoxynivalenol, DON) and Aspergillus carbonarius (ochratoxin A, OTA) respectively. In an attempt to durably control these infections and to address societal and environmental challenges aiming at reducing the use of plant protection products (French national Ecophyto Plan, European directive 2009/128/EC), the StilDeTox project aims at exploiting the biological activity of phenolic extracts. Among phenolic compounds, stilbenes are highly involved in plant defense reactions against pathogens. Few studies report their antifungal properties, however preliminary promising results revealed their potential to reduce F. graminearum growth and DON production. In the interest of sustainable development, grape by-products, rich and abundant sources of stilbenoid, could be valued as a natural fungicide and anti-mycotoxin agent against pathogens contaminating wheat and grapevine. This PhD project will be organised in two modules: Module 1: Screening of stilbenoid extracts for their ability to inhibit the growth of toxicogenic fungi and their production of mycotoxins. The extracts will be obtained from various vine co-products and by different extraction methods. They will be evaluated in vitro for their antifungal (F. graminearum and A. carbonarius) and anti-mycotoxin (DON and OTA) activity. The biological assays will be conducted in the Research Unit Mycology and Food Safety (MycSA, UR 1264, INRA). An untargeted metabolomics study will be employed, using liquid chromatography-mass spectrometry (LC-MSn) data and molecular networks, to highlight compounds or combination of compounds that could be involved in the fungicidal and antimycotoxin effect. A database gathering the overall results will be built. Module 2: Identification of the molecules responsible for the bioactivity. After selecting the most promising extracts, a bioactivity-guided fractionation will be handled through LC and centrifugal partition chromatography (CPC). For each metabolite, bioactivity scores will be calculated to assist the bioguided fractionation. The isolated compounds will be characterised thanks to modern spectroscopic analyses (MS, NMR). Both an analytical method (LC-UV or LC-MS) and a molecular method (RT-QPCR targeting appropriate fungal genes) will be developed, to serve as quality control tests certifying the bioactivity of extracts. Jobs 1-3 of 5 Page 2 This job listing was created using Job Manager for WordPress, by Tom Townsend.