Industry Title Sr. Scientist/Pri. Scientist, Natural Products Chemistry Categories Industry Organization LifeMine Therapeutics Location Cambridge, MA Website http://www.lifeminetx.com Contact email@example.com Job Information Senior Scientist /Principal Scientist, Natural Product Chemistry We are seeking a Senior Scientist / Principal Scientist for our Cambridge site with deep expertise in metabolite profiling and natural product isolation / structure determination strategies to lead a portion of our discovery efforts. This individual should have a demonstrable track record of having isolated complex natural products and elucidated their structures via state-of-the-art techniques and data interpretation including mass spectroscopic (MS) fragmentation patterns and 1- and 2D nuclear magnetic resonance (NMR) data. Substantial hands-on experience with high-resolution MS instruments and liquid chromatography (LC) systems is a must. The successful candidate will be highly motivated and creative, will thrive in a nimble, fast-paced, and performance-oriented environment, and be able to inspire and lead teams in a matrix reporting environment. KEY RESPONSIBILITIES • Lead a matrixed team in the acquisition and interpretation of MS/MS data, particularly fragmentation patterns, to identify and characterize complex natural products expressed by fungi. • Develop LC-MS/MS methods for quantitation of secondary metabolites from fungal extracts. • Develop methods for extractions, and isolation and purification of natural products from fermentation cultures at analytical and preparative scale. • Analyze/interpret NMR data from 1D and 2D homo- and heteronuclear to elucidate three-dimensional structures including relative stereochemistry. • Ability to perform semi-synthesis and derivatization of natural products to assist with structure elucidation and SAR studies would be a plus. • Evaluate new technologies for metabolite profiling and characterization. • Maintain chromatography and mass spectrometry instrumentation and associated analytical software. • Build and maintain strong working relationships with fellow colleagues within and across functional areas. • Deliver high-quality results, interpretation and reports to Discovery project teams and other R&D fora. PROFESSIONAL EXPERIENCE/QUALIFICATIONS • PhD in Natural Product Chemistry or related Chemistry field of study. • At least 5 years of industry experience in natural products discovery. • Experience with chromatography and MS method development, strong familiarity and aptitude with LC and MS instrumentation including automation, and experience in mass spectrometry data analysis and software including automated and manual interpretation of MS/MS fragmentation data. • Ability to rapidly distinguish known from novel natural products, and assignment of chemotype and substituents, based on UV-Vis/MS spectral data (dereplication). • A working knowledge of natural product biosynthetic pathways for polyketides and nonribosomal peptides. • Expertise in the set-up and use of 1D and 2D NMR experiments for structural elucidation and characterization of metabolites. • Knowledge of multiple types of analytical and chromatographic separation techniques, e.g. RPHPLC, HILIC, SAEX, SEC, SPE and SFC. • Strong computer skills and experience with software driven metabolite profiling (Agilent MassHunter, Waters MassLynx and Thermo Scientific Xcalibur). • Excellent written and verbal communication skills. • A record of publishing leading scientific papers in both specialized and general-audience journals is a plus. • Demonstrated ability to lead and inspire a matrixed team toward shared goals. • A sense of adventure and excitement to build a new drug discovery paradigm. • Excellent interpersonal skills working in a collaborative environment and a strong orientation toward, and commitment to, cross-functional collaborations across multiple diverse programs to deliver key results aimed at advancing drug discovery. Title VP, Natural Products Chemistry Categories Industry Organization LifeMine Therapeutics Location Cambridge, MA Website http://www.lifeminetx.com Contact firstname.lastname@example.org Job Information COMPANY DESCRIPTION LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution, with the overall mission to discover and deploy new molecules for the treatment of intractable human diseases via novel biological mechanisms. The company is using genome mining and synthetic biology approaches to mount a massive campaign for finding novel drugs throughout the fungal biosphere. With operations in Cambridge and Gloucester Harbor, MA, and New York, NY, LifeMine brings a unique approach to its revolutionary scientific and medical mission. JOB SUMMARY We are seeking a natural product drug hunter, deeply steeped in leadership of secondary metabolite search-and-retrieval campaigns to lead and expand the Natural Products group at LifeMine. The successful applicant will have a proven track record of creativity, innovation, and success across all facets of natural product drug discovery and development, with broad and deep knowledge of biosynthetic gene cluster architecture and function, natural product biosynthesis, comparative metabolomics, analytical and separation sciences, and structure elucidation. As a member of our R&D leadership team, keys to success in the role will be (i) strategy development and team building (hiring, mentoring, capabilities expansion) and (ii) collaboration across diverse scientific functions (Genomics, Microbiology, Synthetic Biology, Proteomics, Discovery Chemistry, Pharmacology) to advance multiple programs in parallel. Join us as we create a natural product drug discovery engine like none other in existence today. Job Responsibilities • As part of and in collaboration with our R&D leadership team, develop an integrated Natural Products strategy to drive multiple programs in parallel to advance the overall company mission • Inspire and drive high performance across core functions of fermentation extractions, metabolite profiling and comparative metabolomics, analytical and separation sciences, and structure elucidation • Interface with upstream functions – Microbiology and Synthetic Biology – to ensure high impact experiments are designed and executed to drive secondary metabolite identification • Coordinate with downstream functions – Biochemistry, Biophysics, Cell Biology – to efficiently characterize a pipeline of samples spanning multiple programs • Implement new technologies, expand internal capabilities, leverage external collaborations, and develop end-to-end natural products workflows including integration with multiomics and bioinformatic data • Grow the Natural Products group through identification, hiring, development, and retention of exceptional scientists at all levels • Communicate departmental strategy and experimental results to all levels of the organization in formal meetings (including Board of Directors meetings) and informally JOB REQUIREMENTS • Ph.D. in Biochemistry, Chemistry, Chemical Biology, Molecular Microbiology, or a related field with 15+ years post-degree experience • 10+ Years of program leadership and people management • Demonstrated success in directed identification of novel natural products from biosynthetic gene clusters as part of discovery programs • Expertise in fermentation extractions, metabolite profiling and comparative metabolomics, analytical and separation sciences, and structure elucidation (NMR and MSn) • Facility with integration and analysis of large metabolomic datasets with other omics and bioinformatic data • A working knowledge of fungal microbiology and identification of fungal secondary metabolites would be a plus • A proven track record of achievement and invention as evidenced by Investigational New Drug filings, issued patents and patent applications, and publications • Excellent oral and written communication skills and interpersonal skills • The successful candidate will be enthusiastic, innovative, collaborative and have the ability to learn, adapt, and thrive in a dynamic start-up environment Title Chemistry Research Scientist – Pharmacognosy Categories Industry Organization Amway Location Ada, Michigan Website https://jobs.amway.com/US/job/Ada-Chemistry-Research-Scientist-Pharmacognosy-MI/649550900/ Contact Amitabh_Chandra@Amway.com Job Information –What’s special about this team: The Chemistry Investigations and Micro (CIM) dept., in the Division of New Ventures Science & Systems, is a special group within Innovation & Science at Amway, that provides credible, scientific solutions that advance a portfolio of high-quality products and ideas. This division has groups of talented scientists who provide bioassay support, analytical chemistry and chromatography oversight, investigation (forensics) and microbiology support, to product development teams. Our high-quality Amway products, and the active ingredients that make them unique, are supported by research this team provides. Their work is crucial to the discovery and development of new products. Your work on this team will be focused on botanicals and other functional actives for use in both nutrition and beauty ingredients. You will create innovative science concepts during discovery and ideation phases, which will be instrumental in offering innovative and exciting products that fuel sales success and growth for our global Amway Business Owners (ABO’s). –How you would contribute to the role: Amway/Nutrilite is heavily invested in natural ingredients, and your role will support the development of our botanical infrastructure necessary to discover and develop new nutritional products, dietary supplements and personal care products. This industrial position aligns under our corporate goal of driving efficacy and safety-driven selection of botanicals. Working with a collaborative, multi-disciplinary global team that includes analytical, biology, formulation, clinical scientists, product developers, agriculture scientists and statisticians, you will support the delivery of new and innovative science-based health and beauty products. You will partner with Agricultural teams and Plant Agricultural Innovation to support for concept, ideation, strategy and development of global botanical ingredients. Your work will impact exciting product options that our ABO’s want to sell, and consumers want to buy, delighting customers and contributing to sales growth. In addition, your strong experience in establishing and executing laboratory research activities to fulfill international regulatory mandates will be helpful. Your background in research publications with reputed international journals will confirm your expertise in this space. If you love pharmacognosy/natural products chemistry, you will be at home in a company whose foundation is established around, health, wellness, and botanical ingredients. –What skills and background will be important to be successful: PhD and/or Post-doctoral candidate in the filed of pharmacognosy/natural products chemistry Experience with phytochemistry, bioactive natural products Foundational experience with dietary supplements and the skin care industry desirable Working knowledge with a wide range of separation and extraction techniques under various conditions of solvent/temperature Background with standardization for novel extracts, purification & characterization of botanical compounds Experience with traditional herbs from around the world with knowledge of phytochemical processing, and harvest optimization of phytochemicals from botanicals. Experience in botanical / phytochemical research related to pharmacognosy and/or Consumer products related forensic investigation Amway’s exceptional benefits package includes: Medical, dental, prescription and vision insurance; 401(K) participation; Profit Sharing; Bonus Eligibility; Fitness Center; product discounts. Look into how Amway can transform your career! Visit our web site to apply: http://www.amway.jobs. For additional information, check us out at www.linkedIn.com/company/amway, www.facebook.com/AmwayTalent, and www.twitter.com/AmwayTalent. Jobs 1-3 of 3 This job listing was created using Job Manager for WordPress, by Tom Townsend.