|Organization||National Cancer Institute Center for Cancer Research|
|Location||NCI at Frederick Maryland campus|
The Molecular Targets Program (MTP) of the National Cancer Institute’s Center for Cancer Research (NCI’s CCR) has a postdoctoral position available in its Natural Products Chemistry Section. The position is for isolation and structure elucidation of secondary metabolites from a variety of natural sources (microbes, plants, marine organisms, etc.) through a combined approach integrating both bioassay-guided fractionation and modern metabolomic methodologies. The laboratory’s areas of interest include the identification of bioactive natural products with novel structures and unique mode of actions targeting cancer. The selected candidate must have demonstrated expertise in utilization of modern chromatographic (HPLC, LC-MS, etc.) and spectroscopic (NMR, HRMS, IR, CD, etc.) techniques to purification and structure elucidation of low-yield natural products with challenging structural and/or absolute configuration problems. Expertise in one or more of the following areas is desired: natural products synthesis/semi-synthesis in small scales (milligram or sub-milligram), natural products dereplication and structure elucidation using HRMS and MS/MS, DFT calculation of CD spectra, NMR chemical shifts and coupling constants, and/or specific rotation values using computational tools (e.g. Gaussian), and molecular modeling and docking of small molecule ligands with their protein targets. Candidates with hand-on experience in tissue and microbiological culture are particularly encouraged to apply.
The position is located at the NCI-Frederick Maryland campus. The candidates must have a Ph.D. in natural products chemistry, pharmacognosy, medicinal chemistry, pharmaceutical chemistry, or a related discipline from an accredited research institution within the last three years. The fellowship duration is 5 years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. The fellowship stipend starts at $57,600 per annum and is determined based on qualifications and years of relevant experience. Applicants should submit a cover letter, CV with bibliography, and three letters of reference to MTP_PostDoc@nih.gov or directly to Dr. Lin Du at firstname.lastname@example.org.
More information about the Molecular Targets Program is available here:
This position is subject to a background investigation. The NIH is dedicated to building a diverse
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