A POSTDOCTORAL POSITION in drug discovery and chemical biology is available in the laboratories of Prof. Julia Kubanek (http://www.biology.gatech.edu/people/julia-kubanek) and Prof. Mark Hay (http://www.biology.gatech.edu/people/mark-hay) at the Georgia Institute of Technology, funded by the National Institutes of Health International Cooperative Biodiversity Groups (ICBG) program in collaboration with University of California – San Diego and University of the South Pacific in Fiji. The postdoctoral fellow will be located at Georgia Tech in Atlanta, GA, USA, and will be expected to discover new small molecule modulators of biological systems. In particular, expertise in any of these areas is desirable: NMR spectroscopy, mass spectrometry, chromatographic separations, metabolomics, drug design, biosynthesis, synthesis of natural products, bioassay design, high-throughput screening. Thus, a Ph.D. with research experience in organic chemistry, biochemistry, medicinal chemistry, pharmacology, or a related field is expected.
The position is available immediately and will be initially offered for one year with the possibility of renewal dependent upon successful progress in research. The salary is competitive and commensurate with experience. Interested individuals should send a CV, a letter describing career goals, and the names and email addresses of 3 references to Julia Kubanek by e-mail (firstname.lastname@example.org).
Georgia Tech is a unit of the University System of Georgia and an Affirmative Action/Equal Opportunity Employer and requires compliance with Immigration Control Reform Act of 1986.
Post Doctoral/Separation Specialist Oxford, Mississippi
We are seeking a motivated hands-on researcher in natural products. The qualified candidate should have: a PhD in Natural Products or a MS or BS in chemistry or a closely related field; experience in purification of small molecule natural products from microorganisms, marine organisms or plants and good communication and teamwork skills.
The following research skills/knowledge required (or acquired):
• Isolation of natural products by chromatography, both normal and reverse phase prep chromatography
• Familiarity with method development for HPLC analysis of complex natural product preparations/extracts
• Structure and purity analyses using HPLC, LC/MS and NMR data
The following skills/knowledge desired:
• Semi-synthesis of natural products
• Experience in drug discovery programs
The separation and purification of specific natural products from the complex mixtures of natural product extracts routinely employs preparative column chromatography. Column chromatography is a separation technology wherein the mixture to be separated is passed through a column of an adsorbent (the stationary phase) as a solution in a solvent mixture (the mobile phase). The various compounds of the mixture partition between the stationary phase and the mobile phase according to their relative affinity to the two phases (their partition co-efficient). Since the partition co-efficient is a property unique to the specific chemical structure of each compound in the mixture, the compounds will differentially partition between the phases such that those having higher affinity to the mobile phase will be washed through the column most quickly and those having highest affinity for the stationary phase will be retained in the column longest. This differential of rates of passage through the column thereby accomplishes the desired separation. Two contrasting approaches are routinely taken to affect these separations: 1) the mobile phase is less polar (more organic) than the stationary phase; so called “normal” phase chromatography, and 2) the mobile phase is more polar (aqueous) than the stationary phase; so called “reverse” phase chromatography. Reverse phase chromatography is perceived to have economic advantages over normal phase chromatography due to the usual practice of replacement of the normal phase adsorbent after one or at most a few uses whereas the reverse phase adsorbent can be used for hundreds of separations. The gravitation to reverse phase technology for preparative separations has occurred even in spite of the recognized advantages of normal phase chromatography due to significantly greater capacity per column run and ease of compound recovery from the organic solvent of the mobile phase, both very important advantages for production scale separations.
Ironstone Separations has developed propriety technology for the fabrication of high efficiency preparative chromatographic columns applicable to both normal and reverse phase columns and most importantly a technology which regenerates the efficiency of normal phase columns such that they can also be reused for hundreds of separations without adsorbent replacement. These technologies provide cost savings to users of many thousands of dollars over the lifetime of a preparative normal phase chromatographic column. Thus the advantages of normal phase preparative chromatography, increased capacity per column run and ease of purified compound recovery, are captured without the disadvantage of frequent adsorbent replacement.
NIH T-32 Fellowship:
Botanical Approaches to Combat Metabolic Syndrome
The primary aim of this prestigious training grant is to train postdoctoral fellows to understand the biological effects of multicomponent botanicals on the complex interactions between genetic, molecular and physiological aspects of metabolic syndrome.
The fellowship provides two years of funding (with possibility for an additional year) in Dr. Ilya Raskin’s laboratory at Rutgers University, NJ, to join a multi-disciplinary NIH-funded project with the necessary laboratory training and coursework for establishing an independent research career investigating pharmacologically active compounds from plants. The candidate should have strong scientific credentials in the field of botanicals research and human health and wish to pursue program of research and study that combines these areas. Applicant must be a US citizen or Permanent Resident (green card holder).
We seek a postdoctoral fellow with strong scientific credentials and a background in natural products and medicinal chemistry, knowledge of pharmacology and pharmacological screening, skills in molecular and analytical techniques and a strong publication record. Rutgers University is an equal opportunity/affirmative action employer. Fellowships start in January 2015 (possibly earlier in the Fall of 2014).
At the 2014 ASP Meeting (Oxford, MS) please contact Dr. Ilya Raskin (email@example.com); phone 732-794-5600. Thereafter, please send C.V. and the names of three references to Dr. David Ribnicky, Plant Biology and Pathology Department, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901 (firstname.lastname@example.org)
• Purification and characterization of pharmacologically active compounds
• Bioassay development
• Analytical separations, analysis and structure elucidation; heavily focusing on HPLC, MS and NMR work
• Excellent management, organization of data, troubleshooting and presentation skills
• Preclinical development of botanicals that can be used to prevent and combat “modern lifestyle” diseases
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