Post-Doctoral

Title Natural Product Chemist/Bioanalytical Chemist
Categories Post-Doctoral
Organization McMaster University
Location Ontario, Canada
Website http://magarveylab.ca
Contact magarv@mcmaster.ca
Job Information

We are seeking to hire an experienced analytical/organic chemist whose principle responsibility will be the isolation, purification, and structural elucidation of organic substances derived from microbial cultures. Demonstrated experience in chromatographic separations, LC-MS, LC-MS/MS and NMR techniques. Excellent communication skills will also be required and proficiency in scientific writing. One of the key responsibilities will be the coordination of natural product extract screenings across a consortium (with partners in France, Israel, United Kingdom and other Canadian teams) using a genomics/metabolomics pipeline that will direct a genomes to natural product discovery paradigm. Ultimately however the key skills will be excellent skills in elucidating the structures of complex small molecules using 2D NMR techniques as demonstrated through publications and other works. Other key responsibilities will be work in close conjunction with a team of informatic (bio/chemoinformatic) scientists to develop compound identification logic arising from genomics/metabolomics data that will be used to facilitate downstream discovery of new natural products for antibacterial and other activity screening platforms.

 

 The candidate will join and be responsible for scientific interactions amoung an international team (EVOBIOTIC Consortia) that is Dedicated to the Mining of the Natural Antibiotics. Underpinning the strategy of this multi-national consortium to discover antibiotics that kill drug resistant organisms is a computational framework (bioinformatic and chemoinformatic) dedicated to natural product discovery. This framework comprises several web-deployed software packages that will be shared amoungst the team – that contains several algorithimic metabolomic and chemoinformatic strategies to uncover hidden antibiotics and selectively isolate them. The consortium has acquired funding from funding agencies in France, Israel, United Kingdom and Canada.

 

 Please respond with a cover letter and resume (as a single formatted word processing document/or pdf) to: Professor Nathan A. Magarvey Canada Research Chair in Natural Products and Chemical Biology at magarv@mcmaster.ca, If additional information is required please direct inquiries to Phone 905 525 9140 ext 22244

 


Title Research scientist – Marine Natural Product Chemist
Categories Post-Doctoral
Organization Helmholtz-Centre of Ocean Research (GEOMAR): research unit Marine Natural Products Chemistry
Location Am Kiel-Kanal 44, 24106 Kiel, Germany
Website http://www.geomar.de/service/jobs/stellenangebote/article/research-scientist-marine-natural-product-chemist/
Contact dtasdemir@geomar.de
Job Information

The Helmholtz-Centre of Ocean Research (GEOMAR) is one of the leading institutes in marine research in Germany. With 850 employees and a yearly budget of 70 Mio € its major goal is fundamental and applied research in all areas of marine sciences. For more information please visit www.geomar.de. The GEOMAR, division of Marine Ecology is offering a position for a

Research scientist – Marine Natural Product Chemist in the research unit Marine Natural Products Chemistry

Job Description

We are seeking a highly motivated and enthusiastic candidate with clearly demonstrated expertise in marine natural product chemistry to join our Research Unit. The holder of this post will perform a range of research tasks including sampling, generation and dereplication of extracts, purification and structure elucidation of their bioactive molecules by modern analytical methods.

Current research foci of our group encompass discovery of drug leads and functional ingredients from coastal and deep-sea marine invertebrates, microorganisms and seaweeds in the areas of pharmaceutical, nutrition and cosmetics; marine metabolomics; and chemical ecology. The successful candidate will be involved in various projects in these directions. Assistance in the collection of marine materials, which may involve several weeks of expeditions, supervision of postgraduate/undergraduate students, participation in teaching and preparations of third-party funding proposals will be expected The occupant will interact and collaborate with a broad range of scientific disciplines.

Our laboratory has state-of-the-art chemical facilities, including DAD-ELSD-HPLC, DAD-MS-HPLC, LC-MS, HRMS-HPLC, GC-MS, FPLC, FCPC, spectral analytics and the related compound and spectral databases. The GEOMAR has full access to the Department of Chemistry and their high resolution NMR facilities. Our in-house microbial culturing facilities span from small to large-scale (300L fermenter), as well as access to sequencing facilities. We are also members of several multi-institutional excellence clusters, such as The Future Ocean and international consortia.

Qualifications required:
• A PhD in marine natural products chemistry
• Demonstrated competence and experience in analytical techniques for profiling and dereplication of marine natural products by HPLC, GC-MS, LC-MS, NMR and others
• Proficiency in commercial and in house databases
• Extensive competence and experience in purification of diverse types of natural products (by HPLC and other chromatographic methods)
• Demonstrated experience in structure elucidation of marine natural products by high field NMR, HRMS, LC-MS, UV, IR
• Scientific publication in high-ranking journals and dissemination of results at conferences
• Demonstrated experience in writing publications, conference papers and research proposals
• Scuba diving licence and some collection experience
• A full driving licence
• Fluency in spoken and written English and excellent oral and written communication skills
• Planning and organisational skills, prioritisation of multiple tasks, meeting strict deadlines
• Excellent project and laboratory management skills in multiple tasks
• Capability of creative- and critical thinking, independent thought and experimentation, decision making, problem solving with discretion, self-motivation and curiosity.

This is a full-time position, starting 1st March 2015 (or as soon as possible thereafter), The position cannot be split and is available for 3 years. Upon successful review, it can be made permanent. The salary depends on qualification up to the class 13 TVÖD of the German salary rate for public employees.

Working language in the group is English. The GEOMAR is an equal opportunity employer and encourages female scientists and scientists with disabilities to apply. Provided equal qualification, they will be preferentially considered.

Please send your applications containing i. Your CV ii. Contact information for three references ii. A cover letter explaining interest in the position and career goals, no later than 1st February 2015 by e-mail in a single pdf-file to the personnel office Ms. Frauke Lafrenz (Email: flafrenz@geomar.de).

Please put keyword „MaNaProChem_MNTasdemir“ in subject line of e-mail when submitting application.

For further information please contact Prof. Deniz Tasdemir (dtasdemir@geomar.de).

 


Title Research scientist – Marine Metabolomics
Categories Post-Doctoral
Organization Helmholtz-Centre of Ocean Research (GEOMAR): research unit Marine Natural Products Chemistry
Location Am Kiel-Kanal 44, 24106 Kiel, Germany
Website http://www.geomar.de/service/jobs/stellenangebote/article/research-scientist-marine-metabolomics/
Contact dtasdemir@geomar.de
Job Information

The Helmholtz-Centre of Ocean Research (GEOMAR) is one of the leading institutes in marine research in Germany. With 850 employees and a yearly budget of 70 Mio € its major goal is fundamental and applied research in all areas of marine sciences. For more information please visit www.geomar.de. The GEOMAR, division of Marine Ecology is offering a position for a

Research scientist – Marine Metabolomics in the research unit Marine Natural Products Chemistry

Job Description

We are seeking a highly skilled and motivated candidate with clearly demonstrated expertise in marine metabolomics to join our Research Unit. The holder of this post will perform a range of analytical research tasks, using various methodologies, such as targeted metabolomics, non-targeted metabolomic profiling and metabolomic fingerprinting.

The present research foci of our group rest on 1. discovery of bioactive natural products and functional ingredients 2. marine metabolomics 3. chemical ecology. The holder of the post will participate in various projects related to these subjects and will develop strong competence in comparative metabolomics and marine environmental metabolomics on marine macro- and microorganisms. Interactions across a broad range of scientific disciplines with other research groups at GEOMAR and University of Kiel will be expected. The successful candidate will involve in supervision of postgraduate/undergraduate students, teaching and preparations of third-party funding proposals. Candidates with strong track records of accomplishment in terrestrial plant/microbe metabolomics are also encouraged to apply, provided they have sufficient skills and experience.

State-of-the-art chemical facilities are available in our laboratory, including DAD-ELSD-HPLC, DAD-MS-HPLC, LC-MS, HRMS-HPLC, GC-MS, FPLC, FCPC, spectral analytics and the related compound and spectral databases. The GEOMAR has full access to the Department of Chemistry and their high resolution NMR facilities. We are members of several excellence clusters, such as The Future Ocean and several international consortia.

Qualifications required:
• A PhD on metabolomics of marine natural products or a related field
• Demonstrated competence in analytical techniques for metabolomics by GC-MS, LC-MS, NMR and other relevant techniques
• Proficiency in various databases
• High competence in bioinformatics tools and statistical analyses for data analysis/treatment/
standardization
• Experience in writing publications, conference papers and research proposals
• Fluency in spoken and written English and excellent oral and written communication skills
• Planning and organisational skills, prioritisation of multiple tasks, meeting strict deadlines
• Demonstrated project and laboratory management skills in multiple tasks
• Capability of creative- and critical thinking, independent thought and experimentation, decision making, problem solving with discretion, self-motivation and curiosity

Hands-on experience on metabolomics analysis of multiple classes of natural products is advantageous. Scuba diving license and some marine collection experience and prior experience in purification and structure elucidation of new marine signalling metabolites by LC-MS and NMR are highly desirable.

This is a full-time position, starting
1st March 2015 (or as soon as possible thereafter). The position cannot be split and is available for 3 years. Upon successful review, it can be made permanent. The salary depends on qualification up to the class 13 TVÖD of the German salary rate for public employees.

Working language in the group is English. The GEOMAR is an equal opportunity employer and encourages female scientists and scientists with disabilities to apply. Provided equal qualification, they will be preferentially considered.

Please send your applications containing i. Your CV ii. Contact information for three references iii. A cover letter explaining interest in the position and career goals, no later than 1st February 2015 by e-mail in a single pdf-file to the personnel office Ms. Frauke Lafrenz (Email: flafrenz@geomar.de).

Please put keyword „Metabolomics_MNTasdemir“ in subject line of e-mail when submitting application.

For further information please contact Prof. Deniz Tasdemir (dtasdemir@geomar.de)

 

 


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