Post-Doctoral

Title Drug Discovery and Chemical Biology
Categories Post-Doctoral
Organization Georgia Institute of Technology
Location Atlanta
Website http://www.biology.gatech.edu/about/job/postdoctoral-position-drug-discovery-and-chemical-biology
Contact julia.kubanek@biology.gatech.edu
Job Information

 

A POSTDOCTORAL POSITION in drug discovery and chemical biology is available in the laboratories of Prof. Julia Kubanek (http://www.biology.gatech.edu/people/julia-kubanek) and Prof. Mark Hay (http://www.biology.gatech.edu/people/mark-hay) at the Georgia Institute of Technology, funded by the National Institutes of Health International Cooperative Biodiversity Groups (ICBG) program in collaboration with University of California – San Diego and University of the South Pacific in Fiji. The postdoctoral fellow will be located at Georgia Tech in Atlanta, GA, USA, and will be expected to discover new small molecule modulators of biological systems. In particular, expertise in any of these areas is desirable: NMR spectroscopy, mass spectrometry, chromatographic separations, metabolomics, drug design, biosynthesis, synthesis of natural products, bioassay design, high-throughput screening. Thus, a Ph.D. with research experience in organic chemistry, biochemistry, medicinal chemistry, pharmacology, or a related field is expected.

 

 

 

 The position is available immediately and will be initially offered for one year with the possibility of renewal dependent upon successful progress in research. The salary is competitive and commensurate with experience. Interested individuals should send a CV, a letter describing career goals, and the names and email addresses of 3 references to Julia Kubanek by e-mail (julia.kubanek@biology.gatech.edu).

 

 

 

 Georgia Tech is a unit of the University System of Georgia and an Affirmative Action/Equal Opportunity Employer and requires compliance with Immigration Control Reform Act of 1986.

 

 


Title Post Doctoral/Separation Specialist
Categories Industry, Post-Doctoral
Organization Ironstone Separations, Inc
Location Oxford, Mississippi
Website none
Contact jdmcchesney@yahoo.com
Job Information

Post Doctoral/Separation Specialist Oxford, Mississippi
We are seeking a motivated hands-on researcher in natural products. The qualified candidate should have: a PhD in Natural Products or a MS or BS in chemistry or a closely related field; experience in purification of small molecule natural products from microorganisms, marine organisms or plants and good communication and teamwork skills.
The following research skills/knowledge required (or acquired):
• Isolation of natural products by chromatography, both normal and reverse phase prep chromatography
• Familiarity with method development for HPLC analysis of complex natural product preparations/extracts
• Structure and purity analyses using HPLC, LC/MS and NMR data
The following skills/knowledge desired:
• Semi-synthesis of natural products
• Experience in drug discovery programs

The separation and purification of specific natural products from the complex mixtures of natural product extracts routinely employs preparative column chromatography. Column chromatography is a separation technology wherein the mixture to be separated is passed through a column of an adsorbent (the stationary phase) as a solution in a solvent mixture (the mobile phase). The various compounds of the mixture partition between the stationary phase and the mobile phase according to their relative affinity to the two phases (their partition co-efficient). Since the partition co-efficient is a property unique to the specific chemical structure of each compound in the mixture, the compounds will differentially partition between the phases such that those having higher affinity to the mobile phase will be washed through the column most quickly and those having highest affinity for the stationary phase will be retained in the column longest. This differential of rates of passage through the column thereby accomplishes the desired separation. Two contrasting approaches are routinely taken to affect these separations: 1) the mobile phase is less polar (more organic) than the stationary phase; so called “normal” phase chromatography, and 2) the mobile phase is more polar (aqueous) than the stationary phase; so called “reverse” phase chromatography. Reverse phase chromatography is perceived to have economic advantages over normal phase chromatography due to the usual practice of replacement of the normal phase adsorbent after one or at most a few uses whereas the reverse phase adsorbent can be used for hundreds of separations. The gravitation to reverse phase technology for preparative separations has occurred even in spite  of the recognized advantages of  normal phase chromatography due to significantly greater capacity per column run and ease of compound recovery from the organic solvent of the mobile phase, both very important advantages for production scale separations.

 

Ironstone Separations has developed propriety technology for the fabrication of high efficiency preparative chromatographic columns applicable to both normal and reverse phase columns and most importantly a technology which regenerates the efficiency of normal phase columns such that they can also be reused for hundreds of separations without adsorbent replacement. These technologies provide cost savings to users of many thousands of dollars over the lifetime of a preparative normal phase chromatographic column. Thus the advantages of normal phase preparative chromatography, increased capacity per column run and ease of purified compound recovery, are captured without the disadvantage of frequent adsorbent replacement.

 


Title Postdoctoral Position in Natural Products in the Kingston Group
Categories Post-Doctoral
Organization Virginia Tech
Location Blacksburg, Virginia, USA
Website http://listings.jobs.vt.edu/postings/51030
Contact dkingston@vt.edu
Job Information

A Postdoctoral Associate position in natural products chemistry is expected to be available starting September 25, 2014 or later in Professor David Kingston’s laboratory in the Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia, 24061. The work will involve the bioassay-guided isolation and structure elucidation of bioactive natural products. Isolation will require the use of modern HPLC equipment, and structure elucidation will require the use of high field 1D- and 2D-NMR spectroscopy and the interpretation of mass spectra. Preference will be given to candidates with excellent hands-on experience with HPLC separations and with NMR spectroscopy and with the isolation and structure elucidation of natural products. Applicants must have received the Ph.D. degree in natural products chemistry or in pharmacognosy or a related field, and preference will be given to candidates with prior postdoctoral experience. The salary will be commensurate with experience, and will include fringe benefits. Appointment will be for one year in the first instance, but may be renewed by mutual agreement.

Information on the Kingston Group is available at www.kingston.chem.vt.edu

Virginia Tech has a strong tradition of natural products research, and is well equipped with 600 MHz NMR and high-resolution mass spectrometry facilities. The town of Blacksburg is about 40 miles southwest of Roanoke in Southwest Virginia, and the cost of living is significantly lower than in major metropolitan areas.

Candidates wishing to apply for this position must submit an online application on the Virginia Tech Personnel Services website: https://jobs.vt.edu. Search for posting number SR0140129, where further details on the position and information on how to apply for it are provided. Applications should complete the faculty application and attach a letter of application, a copy of the applicant’s most recent curriculum vitae, and a list of three professional references. Reference letters are not needed initially, but may be requested later. Consideration of applications will begin on September 8, 2014, and will continue until the position is filled.

Virginia Tech does not discriminate against employees, students, or applicants on the basis of age, color, disability, gender, national origin, political affiliation, race, religion, sexual orientation, genetic information, veteran status, or any other basis protected by law.

 


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