|Title||Senior Scientist / Principal Scientist, Natural Product Chemistry|
|Location||30 Acorn Park Drive, Cambridge, MA 02140|
LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution, with the overall mission of discovering and deploying new molecules for the treatment of intractable human diseases. The company is using genomic sequencing, advanced bioinformatics including artificial intelligence, and state-of-the-art synthetic biology to search the fungal biosphere for drug candidates that solve biological problems previously thought to be intractable, and to provide these breakthrough drugs to patients in serious need. With operations in Cambridge, Massachusetts, and Manhattan, New York, LifeMine brings a revolutionary scientific approach to a compelling medical mission.
We are seeking a Senior Scientist / Principal Scientist for our Cambridge site with deep expertise in metabolite profiling and natural product isolation / structure determination strategies to lead a portion of our discovery efforts. This individual should have a demonstrable track record of having isolated complex natural products and elucidated their structures via state-of-the-art techniques and data interpretation including mass spectroscopic (MS) fragmentation patterns and 1- and 2D nuclear magnetic resonance (NMR) data. Substantial hands-on experience with high-resolution MS instruments and liquid chromatography (LC) systems is a must. The successful candidate will be highly motivated and creative, will thrive in a nimble, fast-paced, and performance-oriented environment, and be able to inspire and lead teams in a matrix reporting environment.
• Lead a matrixed team in the acquisition and interpretation of MS/MS data, particularly fragmentation patterns, to identify and characterize complex natural products expressed by fungi.
• PhD in Natural Product Chemistry or related Chemistry field of study.