Job Description - LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution and deploying these molecules for the treatment of intractable human diseases via novel biological mechanisms. The company is using a genome mining and recombinant overexpression approach to mount a massive search for novel drugs through the fungal biosphere. With operations in Cambridge and Gloucester, Massachusetts, LifeMine brings a unique approach to its revolutionary scientific and medical mission.SummaryWe are seeking an experienced fermentation process development expert to execute robust and scalable, fermentations using filamentous fungi for production of natural products in support of LifeMine’s genomically-enabled drug discovery platform.
Responsibilities - •Plan and conduct filamentous fungal fermentations using bioreactors at multiple scales •Establish and optimize seed strains for various wild-type and genetically engineered fungal strains targeted for large-scale fermentation production•Identify and implement fermentation productivity improvements and cost reductions by applying quality by design (QbD), scientific and engineering principles, as well as statistical process design and analysis•Apply current industry best practices, proactively evaluate new technologies, stay current with relevant literature, and implement new features and functionality in the bioprocess development platform•Engage in close, cross-functional collaborations with LifeMine’s Genomics, Strain Engineering, Microbiology, Natural Product Chemistry, and Bioinformatics groups to interpret data, reach conclusions, and make decisions•Ensure safe and axenic operation of all fermentation equipment
Qualifications - •BS, MS, or PhD in chemical engineering or related field with 2+ years of experience in fermentation process development using filamentous microbes•Microbial fermentation expertise with bioreactors at multiple scales using non-conventional microbes. Filamentous fungal experience highly preferred.•Knowledge of and hands-on experience with fermentation process design, optimization (DOE), and mixing/mass transfer •Working experience with applying Quality by Design (QbD) concepts and statistical process design and analysis such as JMP and SpotFire•Ability to identify complex problems, review data to determine root cause, evaluate options and implement solutions•Demonstrated ability to work independently as well as in team environment, multitask and ensure flexibility in a dynamic environment required•An understanding of Six Sigma and lean manufacturing principles preferred
Job Confirmation # - 204784276
Website - lifeminetx.com
Email - firstname.lastname@example.org