Employment Opportunities Title Senior Scientist / Principal Scientist, Natural Product Chemistry Categories Industry Organization LifeMine Therapeutics Location 30 Acorn Park Drive, Cambridge, MA 02140 Website https://lifeminetx.com/#careers Contact firstname.lastname@example.org Job Information Senior Scientist / Principal Scientist, Natural Product Chemistry We are seeking a Senior Scientist / Principal Scientist for our Cambridge site with deep expertise in metabolite profiling and natural product isolation / structure determination strategies to lead a portion of our discovery efforts. This individual should have a demonstrable track record of having isolated complex natural products and elucidated their structures via state-of-the-art techniques and data interpretation including mass spectroscopic (MS) fragmentation patterns and 1- and 2D nuclear magnetic resonance (NMR) data. Substantial hands-on experience with high-resolution MS instruments and liquid chromatography (LC) systems is a must. The successful candidate will be highly motivated and creative, will thrive in a nimble, fast-paced, and performance-oriented environment, and be able to inspire and lead teams in a matrix reporting environment. Job Responsibilities • Lead a matrixed team in the acquisition and interpretation of MS/MS data, particularly fragmentation patterns, to identify and characterize complex natural products expressed by fungi. • Develop LC-MS/MS methods for quantitation of secondary metabolites from fungal extracts. • Develop methods for extractions, and isolation and purification of natural products from fermentation cultures at analytical and preparative scale. • Analyze/interpret NMR data from 1D and 2D homo- and heteronuclear to elucidate three-dimensional structures including relative stereochemistry. • Ability to perform semi-synthesis and derivatization of natural products to assist with structure elucidation and SAR studies would be a plus. • Evaluate new technologies for metabolite profiling and characterization. • Maintain chromatography and mass spectrometry instrumentation and associated analytical software. • Build and maintain strong working relationships with fellow colleagues within and across functional areas. • Deliver high-quality results, interpretation and reports to Discovery project teams and other R&D fora. Job Requirements • PhD in Natural Product Chemistry or related Chemistry field of study. • At least 5 years of industry experience in natural products discovery. • Experience with chromatography and MS method development, strong familiarity and aptitude with LC and MS instrumentation including automation, and experience in mass spectrometry data analysis and software including automated and manual interpretation of MS/MS fragmentation data. • Ability to rapidly distinguish known from novel natural products, and assignment of chemotype and substituents, based on UV-Vis/MS spectral data (dereplication). • A working knowledge of natural product biosynthetic pathways for polyketides and non-ribosomal peptides. • Expertise in the set-up and use of 1D and 2D NMR experiments for structural elucidation and characterization of metabolites. • Knowledge of multiple types of analytical and chromatographic separation techniques, e.g. RP-HPLC, HILIC, SAEX, SEC, SPE and SFC. • Strong computer skills and experience with software driven metabolite profiling (Agilent MassHunter, Waters MassLynx and Thermo Scientific Xcalibur). • Excellent written and verbal communication skills. • A record of publishing leading scientific papers in both specialized and general-audience journals is a plus. • Demonstrated ability to lead and inspire a matrixed team toward shared goals. • A sense of adventure and excitement to build a new drug discovery paradigm. • Excellent interpersonal skills working in a collaborative environment and a strong orientation toward, and commitment to, cross-functional collaborations across multiple diverse programs to deliver key results aimed at advancing drug discovery. Company Description LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution, with the overall mission of discovering and deploying new molecules for the treatment of intractable human diseases. The company is using genomic sequencing, advanced bioinformatics including artificial intelligence, and state-of-the-art synthetic biology to search the fungal biosphere for drug candidates that solve biological problems previously thought to be intractable, and to provide these breakthrough drugs to patients in serious need. With operations in Cambridge, Massachusetts, and Manhattan, New York, LifeMine brings a revolutionary scientific approach to a compelling medical mission. Title Chemistry Research Scientist – Pharmacognosy Categories Industry Organization Amway Location Ada, Michigan Website https://jobs.amway.com/US/job/Ada-Chemistry-Research-Scientist-Pharmacognosy-MI/649550900/ Contact Amitabh_Chandra@Amway.com Job Information –What’s special about this team: The Chemistry Investigations and Micro (CIM) dept., in the Division of New Ventures Science & Systems, is a special group within Innovation & Science at Amway, that provides credible, scientific solutions that advance a portfolio of high-quality products and ideas. This division has groups of talented scientists who provide bioassay support, analytical chemistry and chromatography oversight, investigation (forensics) and microbiology support, to product development teams. Our high-quality Amway products, and the active ingredients that make them unique, are supported by research this team provides. Their work is crucial to the discovery and development of new products. Your work on this team will be focused on botanicals and other functional actives for use in both nutrition and beauty ingredients. You will create innovative science concepts during discovery and ideation phases, which will be instrumental in offering innovative and exciting products that fuel sales success and growth for our global Amway Business Owners (ABO’s). –How you would contribute to the role: Amway/Nutrilite is heavily invested in natural ingredients, and your role will support the development of our botanical infrastructure necessary to discover and develop new nutritional products, dietary supplements and personal care products. This industrial position aligns under our corporate goal of driving efficacy and safety-driven selection of botanicals. Working with a collaborative, multi-disciplinary global team that includes analytical, biology, formulation, clinical scientists, product developers, agriculture scientists and statisticians, you will support the delivery of new and innovative science-based health and beauty products. You will partner with Agricultural teams and Plant Agricultural Innovation to support for concept, ideation, strategy and development of global botanical ingredients. Your work will impact exciting product options that our ABO’s want to sell, and consumers want to buy, delighting customers and contributing to sales growth. In addition, your strong experience in establishing and executing laboratory research activities to fulfill international regulatory mandates will be helpful. Your background in research publications with reputed international journals will confirm your expertise in this space. If you love pharmacognosy/natural products chemistry, you will be at home in a company whose foundation is established around, health, wellness, and botanical ingredients. –What skills and background will be important to be successful: PhD and/or Post-doctoral candidate in the filed of pharmacognosy/natural products chemistry Experience with phytochemistry, bioactive natural products Foundational experience with dietary supplements and the skin care industry desirable Working knowledge with a wide range of separation and extraction techniques under various conditions of solvent/temperature Background with standardization for novel extracts, purification & characterization of botanical compounds Experience with traditional herbs from around the world with knowledge of phytochemical processing, and harvest optimization of phytochemicals from botanicals. Experience in botanical / phytochemical research related to pharmacognosy and/or Consumer products related forensic investigation Amway’s exceptional benefits package includes: Medical, dental, prescription and vision insurance; 401(K) participation; Profit Sharing; Bonus Eligibility; Fitness Center; product discounts. Look into how Amway can transform your career! Visit our web site to apply: http://www.amway.jobs. For additional information, check us out at www.linkedIn.com/company/amway, www.facebook.com/AmwayTalent, and www.twitter.com/AmwayTalent. Title Laboratory Analyst Categories Industry Organization Steep Hill Location Pennsylvania Website https://www.steephill.com/locations/pennsylvania Contact email@example.com Job Information POSITION SUMMARY: This is an analytical position responsible for advanced laboratory support functions to include calibration, standard preparation, instrument tuning, instrument and equipment maintenance, and analysis of data used for laboratory quality control. Daily work involves the use of various types of machinery, lab equipment and complex computer programs to perform tests, record data or findings and present information. ESSENTIAL DUTIES: • Works with Department Head to ensure lab efficiencies for prioritization, workflow, and sample preparation, as well as the loading and running of instruments • Identifies opportunities for improvement; works with Department Head to implement new and improved methods and processes • Assists with the upkeep and improvement of the quality management system to include Standard Operating Procedures (SOP’s) and the employee training programs • Prepares calibrations and verifies quality controls for laboratory instruments and methods; uses data to recognize and/or correct possible processing or instrument errors • Acquires and analyzes data used to perform and report analytical laboratory testing of cannabis products • Assists with the validation of test methods and with Research and Development (R&D) related activities • Imports data into LIMS and Seed-to-Sale systems; provides for the documentation and tracking of Continuing Calibration Verification (CCV) Standards for Quality Assurance • Prepares reports related to cannabinoid potency, terpene potency, residual solvents, heavy metals, pesticides, microbiologic organisms, water activity and mycotoxins • Submits data reports and Certificates of Analysis for Department Head approval • Provides guidance and support for all duties commonly assigned to Field Samplers and Lab Technicians • May also be called upon to perform the same or similar duties at other laboratory facilities, and for other job-related duties as assigned POSITION REQUIREMENTS: General Knowledge/Abilities • Ability to fluently speak and read the English language along with understanding and following both written and verbal direction • Ability to function independently, have personal integrity, flexibility and the ability to work effectively with fellow employees • Analytical and numerical skills: ability to perform mathematical calculations in different units of measurement • Ability to use concepts such as fractions, percentages, and ratios; demonstrated abilities in troubleshooting and problem-solving • Basic knowledge of modern office practices and use of Microsoft Office Suite for Word and Excel • Experience in driving tasks and meeting deadlines; accountable for the completion of assigned goals and objectives • Ability to build relationships to strengthen partnerships with a focus on customer service • Ability to perform physically demanding work such as moving and lifting equipment, standing for long periods of time, etc. Experience, Education, Licenses/Certifications • Bachelor’s degree in Chemistry or a related field from an accredited college or university, or an equivalent combination of education and experience SUPERVISORY RESPONSIBILITIES: None Jobs 1-3 of 6 Page 2 This job listing was created using Job Manager for WordPress, by Tom Townsend.