HOT TOPICS IN PHARMACOGNOSY: The Evolution of Dolastatin 10 Derivatives as Sources of ADC Warheads
By David Newman, DPhil
Though natural product chemists who specialize in marine-sourced agents are usually aware of the contribution of structures based upon dolastatin 10 as warheads in antibody-drug conjugates (ADCs), targeted against cancers of varying etiologies, the majority of…